Seminários do Departamento de Física, CEFITEC e LIBPhys: Skin Tissue Engineering: the iSkin2 project - Jorge Carvalho Silva- Professor do Departamento de Física

Qua, 26 junho 2019, 14:00 - 16:00
Tipo de evento: 
Departamento de Física, CEFITEC, LIBPhys
Local do evento: 
Sala de Seminário - Nº 213
Localização específica: 
Edifício I

Professora Maria Luísa Carvalho - Ext.: 10571

Skin Tissue Engineering: the iSkin2 project


Physical trauma and burns resulting from thermal, electrical or chemical assault are two of the most common reasons for acute skin wounds resulting in significant cutaneous tissue loss. While the epidermal layer possesses full regenerative capacity, the dermis doesn’t and, upon suffering substantial damage, wound healing is characterised by extensive scarring and contraction, leading to an unpleasant aesthetic outcome and functional loss. Clinical treatment of deep partial and full thickness wounds is therefore very demanding. Despite the large number of biologic and synthetic skin substitutes that have been developed and commercialised during the last 30 years, autografting remains the gold standard in the treatment of severe wounds. This fact is elucidative of the poor cost/performance ratio of commercially available tissue engineered skin substitutes.

The concept we developed - the Skin2 substitute - has the potential to fulfil most of the requirements of an ideal skin substitute and provide surgeons with an effective product at a fair price. Its core design principles are: Skin2 only uses biodegradable materials and autologous cells, can be applied to the patient on the same day he/she is admitted to the hospital and represents a complete therapeutic solution, dispensing further surgical interventions.

During this seminar, a brief overview of the development of commercially available tissue-engineered skin substitutes and some of the results already obtained within the framework of the iSkin2 project and questions still open will be presented.